High concentrations of calmodulin antagonists inhibit accumulation and binding activities of [(3)H]glutamate in rat brain.

Abstract

Sodium- and energy-dependent accumulation of [(3)H]l-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 ?M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The… (More)

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@article{Yoneda1989HighCO, title={High concentrations of calmodulin antagonists inhibit accumulation and binding activities of [(3)H]glutamate in rat brain.}, author={Yukio Yoneda and Keiko Ogita and K Yamada and Tomoko Kouda and T Ohgaki and Shinichi Uchida and Hideo Meguri}, journal={Neurochemistry international}, year={1989}, volume={15 1}, pages={17-23} }