High concentrations of antioxidants may not improve defense against oxidative stress.

@article{Cao1993HighCO,
  title={High concentrations of antioxidants may not improve defense against oxidative stress.},
  author={Guohua Cao and Roy G. Cutler},
  journal={Archives of gerontology and geriatrics},
  year={1993},
  volume={17 3},
  pages={189-201}
}
It is often assumed that the oxygen radical defense could be further improved by higher concentration of antioxidants. But this has not been demonstrated over a wide range of concentrations. There are different types of oxygen radicals produced in the body and the antioxidant protection against them may not positively related to their concentrations. We report here that by using H(2)O(2) with Cu(2+) as an hydroxyl-radical generator in vitro, ascorbic acid shows no oxygen-radical absorbing… CONTINUE READING

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