High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.

@article{Yamada2010HighCO,
  title={High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.},
  author={Michiko Yamada and Ryuichi Tatsumi and Keitaro Yamanouchi and Tohru Hosoyama and Sei-ichi Shiratsuchi and Akiko Sato and Wataru Mizunoya and Yoshihide Ikeuchi and Mitsuhiro Furuse and Ronald E. Allen},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={298 3},
  pages={C465-76}
}
Skeletal muscle regeneration and work-induced hypertrophy rely on molecular events responsible for activation and quiescence of resident myogenic stem cells, satellite cells. Recent studies demonstrated that hepatocyte growth factor (HGF) triggers activation and entry into the cell cycle in response to mechanical perturbation, and that subsequent expression of myostatin may signal a return to cell quiescence. However, mechanisms responsible for coordinating expression of myostatin after an… CONTINUE READING
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Mechano-biology of resident myogenic stem cells: molecular mechanism of stretch-induced activation of satellite cells

  • R Tatsumi, RE Allen
  • Anim Sci J
  • 2008
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