High collagenolytic activity in spontaneously highly metastatic variants derived from a human pancreatic cancer cell line (SUIT-2) in nude mice

@article{Kitamura2000HighCA,
  title={High collagenolytic activity in spontaneously highly metastatic variants derived from a human pancreatic cancer cell line (SUIT-2) in nude mice},
  author={Norio Kitamura and Takeshi Iwamura and Shoji Taniguchi and Hideo Yamanari and Kikuo Kawano and Michael Anthony Hollingsworth and Toshiaki Setoguchi},
  journal={Clinical & Experimental Metastasis},
  year={2000},
  volume={18},
  pages={561-571}
}
Cell lines with high metastatic capacity to the lung were established by sequential passage of a human pancreatic cancer cell line (SUIT-2) through the lung of a nude mouse, via the lateral tail vein and from a subcutaneous inoculum. Cells of the parental SUIT-2 and sublines S2-VPx (x-cycle selection from SUIT-2 cells, by Vein-Pulmonary metastasis-culture) and S2-CPx (x-cycle selection, by Cutis-Pulmonary metastasis-culture) were injected intravenously or subcutaneously into nude mice to… CONTINUE READING
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