High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130.

@article{Pignatti2003HighCL,
  title={High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130.},
  author={Patrizia Pignatti and Laura Ciapponi and Peter R. Galle and Malene Barr{\'e} Hansen and Margherita Massa and Cristina Meazza and Giacomo Paonessa and Daniela Novick and Gennaro Ciliberto and Albarlo Martini and Fabrizio de Benedetti},
  journal={Clinical and experimental immunology},
  year={2003},
  volume={131 2},
  pages={
          355-63
        }
}
We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays, employing human myeloma XG-1 cells and human hepatoma Hep3B cells, detected serum IL-6 levels similar to those measured by the B9 assay and approximately 10-fold lower than the IL… CONTINUE READING
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