High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.

@article{Goon2003HighCF,
  title={High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.},
  author={Peter K C Goon and Tadahiko Igakura and Emmanuel Hanon and Angelina Jane Mosley and Becca Asquith and Keith G. Gould and Graham P Taylor and Jonathan Weber and Charles R. M. Bangham},
  journal={Journal of virology},
  year={2003},
  volume={77 17},
  pages={9716-22}
}
Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4(+) T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4(+) T cells play a role in the pathogenesis of HAM/TSP. 
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Cytokines: interleukin-1 and tumour necrosis factor in inflammation, p. 108–111

  • C. A. Dinarello
  • Oxford textbook of medicine, 4th ed.,
  • 2003

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