High cholesterol level is essential for myelin membrane growth

@article{Saher2005HighCL,
  title={High cholesterol level is essential for myelin membrane growth},
  author={G. Saher and B. Br{\"u}gger and C. Lappe-Siefke and W. M{\"o}bius and R. Tozawa and M. C. Wehr and F. Wieland and S. Ishibashi and K. Nave},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={468-475}
}
Cholesterol in the mammalian brain is a risk factor for certain neurodegenerative diseases, raising the question of its normal function. In the mature brain, the highest cholesterol content is found in myelin. We therefore created mice that lack the ability to synthesize cholesterol in myelin-forming oligodendrocytes. Mutant oligodendrocytes survived, but CNS myelination was severely perturbed, and mutant mice showed ataxia and tremor. CNS myelination continued at a reduced rate for many months… Expand
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