High cholesterol level is essential for myelin membrane growth

@article{Saher2005HighCL,
  title={High cholesterol level is essential for myelin membrane growth},
  author={Gesine Saher and Britta Br{\"u}gger and Corinna Lappe-Siefke and Wiebke M{\"o}bius and Ryuichi Tozawa and Michael C. Wehr and Felix T. Wieland and Shun Ishibashi and Klaus-Armin Nave},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={468-475}
}
Cholesterol in the mammalian brain is a risk factor for certain neurodegenerative diseases, raising the question of its normal function. In the mature brain, the highest cholesterol content is found in myelin. We therefore created mice that lack the ability to synthesize cholesterol in myelin-forming oligodendrocytes. Mutant oligodendrocytes survived, but CNS myelination was severely perturbed, and mutant mice showed ataxia and tremor. CNS myelination continued at a reduced rate for many months… 
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Cholesterol Regulates the Endoplasmic Reticulum Exit of the Major Membrane Protein P0 Required for Peripheral Myelin Compaction
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In vitro and in vivo evidence is provided that high-level cholesterol coordinates P0 export with myelin membrane synthesis, which is required for the correct stoichiometry of myelin components and for myelin compaction.
A critical role for the cholesterol‐associated proteolipids PLP and M6B in myelination of the central nervous system
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A critical role for proteolipids in cholesterol accumulation is demonstrated in the formation of central nervous system myelin by oligodendrocytes requires sterol synthesis and is associated with a significant enrichment of cholesterol in the myelin membrane.
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