High cholesterol level is essential for myelin membrane growth

  title={High cholesterol level is essential for myelin membrane growth},
  author={Gesine Saher and Britta Br{\"u}gger and Corinna Lappe-Siefke and Wiebke M{\"o}bius and Ryuichi Tozawa and Michael C. Wehr and Felix T. Wieland and Shun Ishibashi and Klaus-Armin Nave},
  journal={Nature Neuroscience},
Cholesterol in the mammalian brain is a risk factor for certain neurodegenerative diseases, raising the question of its normal function. In the mature brain, the highest cholesterol content is found in myelin. We therefore created mice that lack the ability to synthesize cholesterol in myelin-forming oligodendrocytes. Mutant oligodendrocytes survived, but CNS myelination was severely perturbed, and mutant mice showed ataxia and tremor. CNS myelination continued at a reduced rate for many months… 
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