High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells.


High cell densities in animal cell culture can be obtained by continuous perfusion of fresh culture medium across hollow fiber membranes that retain the cells. Careful selection of the membrane type and cut-off allows to control accumulation of target molecules and removal of low molecular weight compounds. In this report, perfusion with the scalable ATF… (More)
DOI: 10.1016/j.vaccine.2014.02.016


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