High-cell-density cultivation of microorganisms

  title={High-cell-density cultivation of microorganisms},
  author={Dieter Riesenberg and Reinhard Guthke},
  journal={Applied Microbiology and Biotechnology},
High-cell-density cultivation (HCDC) is required to improve microbial biomass and product formation substantially. An overview of HCDC is given for microorganisms including bacteria, archae and eukarya (yeasts). Problems encountered by HCDC and their possible solutions are discussed. Improvements of strains, different types of bioreactors and cultivation strategies for successful HCDC are described. Stirred-tank reactors with and without cell retention, a dialysis-membrane reactor, a gas-lift… CONTINUE READING

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