High-capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses.

@article{Kron2011HighcapacityAV,
  title={High-capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses.},
  author={Matthias W. Kron and Tatjana Engler and Erika Pina Schmidt and R. Schirmbeck and Stefan Kochanek and Florian Kreppel},
  journal={The journal of gene medicine},
  year={2011},
  volume={13 12},
  pages={
          648-57
        }
}
BACKGROUND The ability to induce cytotoxic T lymphocyte (CTL) responses that are multispecific is considered to comprise an essential feature for an efficacious genetic vaccine against many pathogens including HIV and hepatitis C virus. ΔE1Ad vectors are promising vectored vaccines but have been shown to induce antigen-specific CTLs with only limited multispecificity. In the present study, we investigated the applicability of gene-deleted high-capacity adenovirus (HC-Ad) vectors and focused on… CONTINUE READING
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