High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif.

@article{Hucl2007HighCE,
  title={High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif.},
  author={Tomas Hucl and Jonathan R. Brody and Eike Gallmeier and Christine A Iacobuzio-Donahue and Iain K. G. Farrance and Scott E. Kern},
  journal={Cancer research},
  year={2007},
  volume={67 19},
  pages={
          9055-65
        }
}
Identification of genes with cancer-specific overexpression offers the potential to efficiently discover cancer-specific activities in an unbiased manner. We apply this paradigm to study mesothelin (MSLN) overexpression, a nearly ubiquitous, diagnostically and therapeutically useful characteristic of pancreatic cancer. We identified an 18-bp upstream enhancer, termed CanScript, strongly activating transcription from an otherwise weak tissue-nonspecific promoter and operating selectively in… CONTINUE READING

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