High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism

  title={High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism},
  author={Eva Al{\'e}s and L. Tabares and J. Poyato and Vicente Valero and Manfred Lindau and Guillermo Alvarez de Toledo},
  journal={Nature Cell Biology},
Exocytosis, the fusion of secretory vesicles with the plasma membrane to allow release of the contents of the vesicles into the extracellular environment, and endocytosis, the internalization of these vesicles to allow another round of secretion, are coupled. It is, however, uncertain whether exocytosis and endocytosis are tightly coupled, such that secretory vesicles fuse only transiently with the plasma membrane before being internalized (the ‘kiss-and-run’ mechanism), or whether endocytosis… 
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Exocytosis of Catecholamine (CA)-containing and CA-free Granules in Chromaffin Cells*
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Mechanics of post-fusion exocytotic vesicle.
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Exocytosis and endocytosis: modes, functions, and coupling mechanisms.
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Bilayers merge even when exocytosis is transient.
  • J. Taraska, W. Almers
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
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Synaptic vesicles retain their identity through the endocytic cycle
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The exocytotic event in chromaffin cells revealed by patch amperometry
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Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells
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