High brain densities of the immunophilin FKBP colocalized with calcineurin

THE immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions1,2. The Ca2+-dependent protein phosphatase, calcineurin, binds the cyclophilin—cyclosporin A and FKBP… CONTINUE READING