High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1

@article{Seitz2009HighBT,
  title={High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1},
  author={Sebastian Seitz and Claudia Schnabel and Bj{\"o}rn Busse and Hans Ulrich Schmidt and Frank Timo Beil and Reinhard Edgar Friedrich and Thorsten Schinke and Victor Felix Mautner and Michael Amling},
  journal={Osteoporosis International},
  year={2009},
  volume={21},
  pages={119-127}
}
Although it is known that neurofibromatosis 1 (NF1) patients suffer from vitamin D deficiency and display decreased bone mineral density (BMD), a systematic clinical and histomorphometrical analysis is absent. Our data demonstrate that NF1 patients display high bone turnover and accumulation of osteoid and that supplementation of vitamin D has a beneficial effect on their BMD. Neurofibromatosis 1 results in a wide range of clinical manifestations, including decreased BMD. Although it has been… CONTINUE READING

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