High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years.

@article{Lang2002HighBG,
  title={High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years.},
  author={Calvin A. Lang and B. J. Mills and Helen L Lang and Marica C Liu and Wayne M. Usui and John P. Richie and Walter Mastropaolo and Stanley A. Murrell},
  journal={The Journal of laboratory and clinical medicine},
  year={2002},
  volume={140 6},
  pages={
          413-7
        }
}
Earlier we found a high percentage of subnormal total glutathione (G(T)) levels in blood from elderly subjects and patients with chronic diseases. These findings suggested a hypothesis that high levels of G(T) in the blood occur in old persons who are in excellent physical and mental health. To this end, we recruited 87 white women who ranged in age from 60 to 103 years and reported that they felt healthy. Their health was verified with physical examinations, clinical chemistry profiles… 

Figures and Tables from this paper

Glutathione in the blood and cerebrospinal fluid: A study in healthy male volunteers

Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults

The hypothesis that tGSH is a biomarker of multisystem dysregulation that eventually leads to multimorbidity development is supported, as the association between baseline levels of total serum glutathione (tGSH) and rate of chronic disease accumulation over time is investigated.

Insulin resistance, oxidative stress markers and the blood antioxidant system in overweight elderly men

It was indicated that the increased insulin resistance and hyperglycemia in elderly men are related to body mass and that they cause intensified oxidative modifications of LDL.

Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls

The antioxidant barrier changes in elderly subjects with senescence are analyzed and CuZn SOD activity is negatively correlated with age and this association is not altered by factors that modulate the enzyme activity, such as hypertension and antihypertensive treatment.

Taurine and Glutathione in cerebrospinal fluid and plasma from patients with psychiatric disorders and healthy controls

The significantly higher levels of plasma but not CSF taurine in patients with schizophrenia treated with olanzapine compared with controls may implicate the involvement of taurines in the pathophysiology of the disease.

Malondialdehyde and Measures of Antioxidant Activity in Subjects from the Belfast Elderly Longitudinal Free‐Living Aging Study

The main finding in the BELFAST octo/nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects, whereas conversely antioxidantglutathione peroxidase activity fell in thenonagenarian group.

The concentration of glutathione in human erythrocytes is a heritable trait.

Heritability of the aged glutathione phenotype is dependent on tissue of origin

The emergence of significant correlations suggested that despite tissue-specific heritabilities, at least some shared regulatory mechanisms may exist in the glutathione system, and these data highlight another mechanism by which genetic background determines antioxidant protection and stress resistance.

The interaction of blood glutathione concentration and selenium supplementation on the redox states in skeletal muscles, whole body cysteine metabolism and lipid peroxidation in Merino lambs.

Although blood GSH concentration differed markedly between the high and low GSH groups, the difference in GSH concentrations in the muscles m.

References

SHOWING 1-10 OF 30 REFERENCES

Blood glutathione decreases in chronic diseases.

It is concluded that a decrease in GSH is a risk factor for chronic diseases that may be used to monitor the severity and progress of the diseases.

Low blood glutathione levels in healthy aging adults.

The findings demonstrate an increased incidence of low glutathione levels in apparently healthy elderly subjects, who thus may be at risk because of a decreased capacity to maintain many metabolic and detoxification reactions mediated by glutATHione.

Prevalence of depression and its correlates in older adults.

Older adults with depression would probably be more likely to seek help from physicians than from services or professionals with explicit mental health labels, as well as with self-reported physical health.

Glutathione contents of tissues in the aging mouse.

Results extend the previous results and indicate that a general characteristic of aging tissues may be a decrease in GSH concentrations, consistent with the hypothesis that the reducing potential of tissues decreases in senescence.

Blood glutathione: a biochemical index of life span enhancement in the diet restricted Lobund-Wistar rat.

The experimental results demonstrate that dietary restriction in both conventional and germfree rats results in enhanced longevity compared to fullfed animals and suggests that glutathione may be a molecular mechanism for the diet restriction and longevity phenomenon.

Influence of mouse age and erythrocyte age on glutathione metabolism.

The results in aging erythrocytes from aging mice suggest that the glutathione status the ery Throcyte may be an index of aging, not only of the cell but also of the organism.

Life-long sustained mortality advantage of siblings of centenarians

  • T. PerlsJ. Wilmoth A. Puca
  • Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Siblings of centenarians experienced a mortality advantage throughout their lives relative to the U.S. 1900 cohort, and relative survival probabilities for these siblings increase markedly at older ages, reflecting the cumulative effect of their mortality advantage Throughout life.

Glutathione Levels during the Mosquito Life Span with Emphasis on Senescence

  • G. A. HazeltonC. Lang
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1984
Glutathione levels were determined in mosquitoes of all ages of the life span, and the highest levels of GSH and total glutathione were found during larval growth and metamorphosis, which can lead to lower biosynthetic activity and also impaired detoxification capacity.

Socioeconomic comparisons and life satisfaction of elderly adults.

Findings suggest that life satisfaction reflects not only one's location in the broader stratification system but also one’s location in a rather limited network of significant others.