High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma

@article{Prochzka2012HighBS,
  title={High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma},
  author={V{\'i}t Proch{\'a}zka and Edgar Faber and Luděk Raida and Kateřina Langov{\'a} and Karel Indr{\'a}k and Tom{\'a}{\vs} Papaj{\'i}k},
  journal={Leukemia \& Lymphoma},
  year={2012},
  volume={53},
  pages={1306 - 1310}
}
Abstract Serum thymidine kinase 1 (TK1) is a sensitive marker of tumor cell proliferation. TK1 has been reported as a reliable prognostic factor in solid tumors and chronic lymphocytic leukemia, but has not yet been tested in large populations of patients with non-Hodgkin lymphoma. In this study, the prognostic significance of TK1 levels was assessed in 170 prospectively enrolled patients with previously untreated follicular lymphoma (FL). The TK1 level at the time of treatment initiation was… 

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References

SHOWING 1-10 OF 60 REFERENCES

High serum thymidine kinase 1 level predicts poorer survival in patients with chronic lymphocytic leukemia.

TLDR
It is shown that high serum TK1 levels predict poorer overall survival and correlate with unmutated immunoglobulin variable region genes, CD38 and ZAP-70 expression, and subsequent risk of developing large B-cell lymphoma (Richter syndrome).

High Thymidine Kinase Activity and CD5 Positivity Predict Poor Prognosis Of DLBCL Treated With R-CHOP

TLDR
It is reported that high thymidine kinase activity (TK) predicts poor prognosis for diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP and CD5 positivity was reported as a poor predictor for DLBCL.

Serum thymidine kinase 1 concentration as a prognostic factor of chemotherapy-treated non-Hodgkin’s lymphoma patients

TLDR
Although the number of patients was limited in this study, TK1 in serum might possess an important reference value in the evaluation of treatment and prognosis of non-Hodgkin’s lymphoma following chemotherapy.

Elevated serum thymidine kinase 1 predicts risk of pre/early cancerous progression.

TLDR
Serological TK1 may be a reliable marker for risk assessment of pre/early cancerous progression of breast and prostate hyperplasia and related diseases.

Serological thymidine kinase 1 is a prognostic factor in oesophageal, cardial and lung carcinomas

  • Zhi-shan LiYinghong Wang S. Skog
  • Medicine
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2010
TLDR
STK1 is a useful marker for prognosis in patients with oesophageal, cardial and lung carcinomas and with NSCLC, and there was a tendency that stage I–IINSCLC patients with an STK1 level above 2 pmol/l showed a higher frequency of recurrence/death than patients below 1‬pmol /l.

Prognostic factors in follicular lymphoma in the rituximab era: how to identify a high-risk patient?

TLDR
New therapeutic approaches with MoAb, RIT and other biological agents allow the population to be divided into increasing numbers of groups with different outcomes, and accurate prognostic indices are urgently needed to find optimal therapies for particular lymphoma patients.

Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project.

TLDR
Follicular Lymphoma International Prognostic Index 2 is a simple prognostic index based on easily available clinical data and may represent a promising new tool for the identification of patients with FL at different risk in the era of immunochemotherapy.

Follicular Lymphoma International Prognostic Index.

TLDR
The Follicular Lymphoma International Prognostic Index was designed from the data recorded over 8 years of nearly 5000 patients registered worldwide to help provide an optimal treatment option for patients with follicular lymphoma.

Improved survival of follicular lymphoma patients in the United States.

TLDR
The survival of patients with FL in the United States has improved over the last 25 years, and the survival improvement may be a result of the sequential application of effective therapies and improved supportive care.

The Follicular Lymphoma International Prognostic Index (FLIPI) separates high-risk from intermediate- or low-risk patients with advanced-stage follicular lymphoma treated front-line with rituximab and the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) with respect

TLDR
It is demonstrated that the FLIPI is able to identify high-risk patients with advanced-stage FL after first-line treatment with rituximab/chemotherapy after a prospective trial of the German Low Grade Lymphoma Study Group.
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