High-avidity IgA protects the intestine by enchaining growing bacteria.

@article{Moor2017HighavidityIP,
  title={High-avidity IgA protects the intestine by enchaining growing bacteria.},
  author={Kathrin Moor and M{\'e}d{\'e}ric Diard and Mikael Erik Sellin and Boas Felmy and Sandra Yvonne Wotzka and Albulena Toska and Erik Bakkeren and Markus Arnoldini and Florence Bansept and Alma Dal Co and Tom V{\"o}ller and Andrea Minola and Blanca Maria Fernandez-Rodriguez and Gloria Agatic and Sonia Barbieri and Luca Piccoli and Costanza Casiraghi and Davide Corti and Antonio Lanzavecchia and Roland R. Regoes and Claude Loverdo and Roman Stocker and Douglas R. Brumley and Wolf-Dietrich Hardt and Emma Slack},
  journal={Nature},
  year={2017},
  volume={544 7651},
  pages={498-502}
}
Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly neutralizing virulence factors or by poorly defined mechanisms that physically impede bacterial interactions with the gut tissues ('immune exclusion'). IgA-mediated cross-linking clumps bacteria in the gut lumen and is critical for protection against infection by non-typhoidal Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium). However, classical agglutination, which was thought… CONTINUE READING
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