High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.

@article{Zeh1999HighAC,
  title={High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.},
  author={Herbert J. Zeh and Donna M Perry-Lalley and Mark Edward Dudley and Steven A Rosenberg and James C Yang},
  journal={Journal of immunology},
  year={1999},
  volume={162 2},
  pages={989-94}
}
A majority of the human tumor-associated Ags characterized to date are derived from nonmutated "self"-proteins. Little is currently understood about the nature of the self-reactive lymphocytes that recognize these Ags. We recently characterized two nonmutated tumor-associated Ags for the B16 murine melanoma: tyrosinase-related protein-2 (TRP-2) and the endogenous retroviral envelope protein, p15E. We previously reported that both TRP-2 and p15E reactive CTL could be detected in the spleens of… CONTINUE READING

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