High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers.

Abstract

Delivery of therapeutics into skin is hindered by the epidermal barriers. To overcome these barriers for the treatment of skin diseases, a cutaneous delivery method capable of field treatment using silica-elongated microparticles is developed. The microparticles are massaged into the skin using a 3D-printed microtextured applicator resulting in significant field-directed drug delivery enhancement.

DOI: 10.1002/adhm.201300517

Cite this paper

@article{Raphael2014HighAR, title={High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers.}, author={Anthony P. Raphael and Clare A. Primiero and Lynlee L. Lin and Ross Flewell Smith and Philip A. Dyer and H. Peter Soyer and Tarl W. Prow}, journal={Advanced healthcare materials}, year={2014}, volume={3 6}, pages={860-6} }