High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer.

@article{Bessard2009HighAA,
  title={High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer.},
  author={Anne Bessard and V{\'e}ronique Sol{\'e} and Gr{\'e}gory Bouchaud and Agn{\`e}s Qu{\'e}m{\'e}ner and Yannick Jacques},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 9},
  pages={2736-45}
}
Interleukin (IL)-15 has an important role in tumor immunosurveillance and has a contemplated use in tumor immunotherapy. We have previously engineered the fusion protein RLI, composed of the NH(2)-terminal (amino acids 1-77, sushi+) domain of IL-15 receptor alpha coupled via a linker to IL-15, and shown that it displayed far better efficacy than IL-15 in vitro. In this report, we investigated in vivo whether RLI would be a better alternative than IL-15 and IL-2 for cancer treatment using two… CONTINUE READING

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