High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis.

Abstract

Chinese hamster ovary (CHO) cells are the preferred production host for therapeutic monoclonal antibodies (mAb) due to their ability to perform post-translational modifications and their successful approval history. The completion of the genome sequence for CHO cells has reignited interest in using quantitative proteomics to identify markers of good… (More)
DOI: 10.1021/pr501027c

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Cite this paper

@article{Orellana2015HighantibodyproducingCH, title={High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis.}, author={Camila A Orellana and Esteban Marcellin and Benjamin L Schulz and Amanda S. Nouwens and Peter P. Gray and Lars K. Nielsen}, journal={Journal of proteome research}, year={2015}, volume={14 2}, pages={609-18} }