High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity

@article{Tuch2002HighAR,
  title={High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity},
  author={D. Tuch and T. Reese and M. Wiegell and N. Makris and J. Belliveau and V. Wedeen},
  journal={Magnetic Resonance in Medicine},
  year={2002},
  volume={48}
}
Magnetic resonance (MR) diffusion tensor imaging (DTI) can resolve the white matter fiber orientation within a voxel provided that the fibers are strongly aligned. However, a given voxel may contain a distribution of fiber orientations due to, for example, intravoxel fiber crossing. The present study sought to test whether a geodesic, high b‐value diffusion gradient sampling scheme could resolve multiple fiber orientations within a single voxel. In regions of fiber crossing the diffusion signal… Expand
Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution
TLDR
This study proposes a novel method for estimating the fiber orientation distribution directly from high angular resolution diffusion-weighted MR data without the need for prior assumptions regarding the number of fiber populations present, assuming that all white matter fiber bundles in the brain share identical diffusion characteristics. Expand
A localized Richardson-Lucy algorithm for fiber orientation estimation in high angular resolution diffusion imaging.
TLDR
The novel spherical deconvolution method for improved accuracy in investigating crossing fibers can simultaneously reduce noise and correct Rician bias and is especially suitable for estimation of fiber orientations in HARDI data. Expand
Diffusion Basis Functions Decomposition for Estimating White Matter Intravoxel Fiber Geometry
In this paper, we present a new formulation for recovering the fiber tract geometry within a voxel from diffusion weighted magnetic resonance imaging (MRI) data, in the presence of single or multipleExpand
A multiple streamline approach to high angular resolution diffusion tractography.
TLDR
A modified fiber assignment using the continuous tracking (MFACT) algorithm and a tracking browser to propagate tracts along complex diffusion profiles was proposed and the Q-ball imaging method was adopted to acquire the diffusion displacements. Expand
High angular resolution diffusion MRI : from local estimation to segmentation and tractography
At the current resolution of diffusion-weighted (DW) magnetic resonance imaging (MRI), research groups agree that there are between one third to two thirds of imaging voxels in the human brain whiteExpand
Inferring multiple maxima in intravoxel white matter fiber distribution
TLDR
It is demonstrated that the incomplete signal modeling fails to reconstruct the relative fiber volume fractions, especially when the intravoxel diffusion profiles have dissimilar contributions to the diffusion MRI signal, and the BCDT method proposed here reduces this effect by introducing the Nth‐root correction, making multiple fibers estimable. Expand
Diffusion Simulation Based Tracking: And Optimized Gradient Encoding Schemes For Diffusion Magnetic Resonance Imaging
Diffusion tensor magnetic resonance imaging is the only non-invasive imaging technique that allows the discrimination of different matter types as well as the distinction of matter anatomy. AnatomyExpand
Examination of spinal cord tissue architecture with magnetic resonance diffusion tensor imaging
  • S. Maier
  • Materials Science, Medicine
  • Neurotherapeutics
  • 2011
TLDR
The observation that diffusion along nerve fibers is much higher than across fibers, allows a noninvasive reconstruction of the spinal cord nerve fiber architecture, and a three-dimensional view of axonal fiber connectivity between the spinal Cord and different brain regions is obtained. Expand
Resolving axon fiber crossings at clinical b-values: an evaluation study.
TLDR
The authors study how QBall, spherical deconvolution, persistent angular structure, stick and ball, diffusion basis functions, and analytical QBall methods perform under clinically-realistic scanning conditions, where the b-value is typically lower and the number of diffusion encoding orientations is fewer than in dedicated high angular resolution diffusion imaging scans. Expand
Angular resolution enhancement technique for diffusion-weighted imaging (DWI) using predicted diffusion gradient directions
TLDR
A novel method to improve angular resolution of diffusion MRI acquisition using given diffusion gradient (DG) directions is proposed and provides an enhanced SDF resolution and improved multiple fiber structure by incorporating synthesized signals. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
MR diffusion tensor spectroscopy and imaging.
TLDR
Once Deff is estimated from a series of NMR pulsed-gradient, spin-echo experiments, a tissue's three orthotropic axes can be determined and the effective diffusivities along these orthotropic directions are the eigenvalues of Deff. Expand
In vivo fiber tractography using DT‐MRI data
TLDR
Fiber tract trajectories in coherently organized brain white matter pathways were computed from in vivo diffusion tensor magnetic resonance imaging (DT‐MRI) data, and the method holds promise for elucidating architectural features in other fibrous tissues and ordered media. Expand
Diffusion tensor MR imaging of the human brain.
TLDR
A quantitative characterization of water diffusion in anisotropic, heterogeneously oriented tissues is clinically feasible and should improve the neuroradiologic assessment of a variety of gray and white matter disorders. Expand
The b matrix in diffusion tensor echo‐planar imaging
TLDR
The contributions from readout and phase‐encode gradient pulse trains are predicted to have a negligible effect on the echo, but the contributions from other imaging and diffusion gradient pulses applied in both parallel and orthogonal directions are shown to be significant in this sequence. Expand
Analysis of partial volume effects in diffusion‐tensor MRI
TLDR
A partial volume model of MRI signal behavior for two diffusion‐tensor compartments is presented andSimulations using this model demonstrate that the conventional single diffusion tensor model could lead to highly variable and inaccurate measurements of diffusion behavior. Expand
High Angular Resolution Diffusion Imaging of the Human Brain
Introduction The use of a tensor to describe diffusion in anisotropic tissue such as white matter or cardiac muscle is predicated on the assumption of Gaussian diffusion (I, 2). The diffusion may,Expand
Regularization of Diffusion-Based Direction Maps for the Tracking of Brain White Matter Fascicles
TLDR
A study of the tracking behavior according to the influence given to the a priori knowledge is proposed and concrete tracking results obtained with in vivo human brain data are illustrated. Expand
Diffusion tensor MRI of the spinal cord
TLDR
Changes in the diffusion characteristics were found to be large enough to allow a robust detection of diffusion changes in the spine, even in cases in which conventional T2 and T1 weighted images were unable to detect any lesion. Expand
Anisotropy of water diffusion in the myocardium of the rat.
TLDR
These data suggest that myocardial water diffusion is essentially unrestricted parallel to the myofibers and show that failure to measure the complete diffusion tensor may lead to substantial underestimates of diffusion anisotropy in the myocardium. Expand
Morphometry of in vivo human white matter association pathways with diffusion‐weighted magnetic resonance imaging
TLDR
This method was used to map the “stem” (compact portion) of the principal association, projection, and commissural white matter pathways of the human brain in vivo, in 3 normal subjects and represents an important method for the characterization of major association pathways in the living human that are not discernible by conventional magnetic resonance imaging. Expand
...
1
2
3
...