High and low responders to novelty: effects of a catecholamine synthesis inhibitor on novelty-induced changes in behaviour and release of accumbal dopamine.

@article{Saigusa1999HighAL,
  title={High and low responders to novelty: effects of a catecholamine synthesis inhibitor on novelty-induced changes in behaviour and release of accumbal dopamine.},
  author={Tadashi Saigusa and Tinka Tuinstra and Noriaki Koshikawa and Alexander Rudolf Cools},
  journal={Neuroscience},
  year={1999},
  volume={88 4},
  pages={1153-63}
}
The purpose of the present study was two-fold: (i) to investigate to what extent novelty, i.e. a novel cage with slightly larger dimensions than the home cage and lacking the floor covering that was originally present, produced behavioural effects in high responders to novelty and low responders to novelty that could be correlated with the extracellular amount of accumbal dopamine, using the microdialysis technique, and (ii) to establish the ability of the catecholamine synthesis inhibitor… CONTINUE READING
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