High and low diabetes incidence nonobese diabetic (NOD) mice: origins and characterisation.

@article{Baxter1991HighAL,
  title={High and low diabetes incidence nonobese diabetic (NOD) mice: origins and characterisation.},
  author={Alan G. Baxter and Maria Koulmanda and Tom E. Mandel},
  journal={Autoimmunity},
  year={1991},
  volume={9 1},
  pages={61-7}
}
The Nonobese Diabetic mouse (NOD mouse) is an established model of autoimmune diabetes mellitus. While all colonies of NOD mice are derived from a single diabetic female detected during the breeding of a cataract-prone strain of mice, some of the dispersed colonies have been separated for many generations and express varying levels of diabetes. It is unclear to what extent this is due to environmental factors such as diet factor or a result of the varied origins of the colonies. Here we compare… CONTINUE READING