High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells.


The present study examined the functional characteristics of the inward and outward L-[14C]DOPA and L-[14C]leucine transporters in LLC-PK1 cells. Uptake was initiated by the addition of Hanks' medium with a given concentration of L-[14C]DOPA or L-[14C]leucine. Saturation experiments were performed in cells incubated for 6 min with 0.25 microM concentration… (More)


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