High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells.

@article{SoaresdaSilva2004HighAL,
  title={High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells.},
  author={Patr{\'i}cio Soares-da-Silva and Maria Paula Serr{\~a}o},
  journal={American journal of physiology. Renal physiology},
  year={2004},
  volume={287 2},
  pages={F252-61}
}
The present study examined the functional characteristics of the inward and outward L-[14C]DOPA and L-[14C]leucine transporters in LLC-PK1 cells. Uptake was initiated by the addition of Hanks' medium with a given concentration of L-[14C]DOPA or L-[14C]leucine. Saturation experiments were performed in cells incubated for 6 min with 0.25 microM concentration of the substrates in the absence and the presence of increasing concentrations of the nonlabeled substrates. Fractional outflow of… CONTINUE READING
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