High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease.

@article{Kunugi1997HighAL,
  title={High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease.},
  author={Hiroshi Kunugi and Shinichiro Nanko and Akira Ueki and Eiichi Otsuka and Mineko Hattori and Farzana Hoda and Homero Vallada and Mar{\'i}a Jes{\'u}s Arranz and David A. Collier},
  journal={Neuroscience letters},
  year={1997},
  volume={221 2-3},
  pages={202-4}
}
Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Recently an amino acid change (Val-108-Met) of the COMT protein was found to determine high and low activity alleles of the COMT gene. We genotyped 109 Japanese patients with Parkinson's disease (PD) and 153 controls by using polymerase chain reaction (PCR) amplification and digestion by the restriction enzyme NlaIII. The frequency of low activity allele in… CONTINUE READING