High-amylose sodium carboxymethyl starch matrices for oral, sustained drug-release: formulation aspects and in vitro drug-release evaluation.

@article{Brouillet2008HighamyloseSC,
  title={High-amylose sodium carboxymethyl starch matrices for oral, sustained drug-release: formulation aspects and in vitro drug-release evaluation.},
  author={Fabien Brouillet and Bernard Bataille and Louis Cartilier},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={356 1-2},
  pages={52-60}
}
High-amylose sodium carboxymethyl starch (HASCA), produced by spray-drying (SD), was previously shown to have interesting properties as a promising pharmaceutical sustained drug-release tablet excipient for direct compression, including ease of manufacture and high crushing strength. This study describes the effects of some important formulation parameters, such as compression force (CF), tablet weight (TW), drug-loading and electrolyte particle size, on acetaminophen-release performances from… CONTINUE READING