High ammonia levels in brain induce tubulin in cerebrum but not in cerebellum.

@article{Miana1988HighAL,
  title={High ammonia levels in brain induce tubulin in cerebrum but not in cerebellum.},
  author={Mª Dolores Mi{\~n}ana and Vicente Felipo and Rosalyn Wallace and Santiago Grisol{\^i}a},
  journal={Journal of neurochemistry},
  year={1988},
  volume={51 6},
  pages={1839-42}
}
Ingestion of large amounts of ammonium increases markedly the content of tubulin in brain. The effect on tubulin induction of ammonium ingestion for up to 100 days was investigated. Brain tubulin content showed a rapid initial increase (28%) at 2 days and reached 50% after 100 days on the diet. To discern if ammonia, the increase in urea synthesis, or both was responsible for tubulin induction, rats were maintained at several levels of uremia (by administering diets containing 0 to 80% protein… CONTINUE READING