High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes.

@article{Bai2006HighAG,
  title={High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes.},
  author={Yaling Bai and Lizhu Wang and Yongqiang Li and Senyan Liu and Jingzi Li and Haiyan Wang and Haichang Huang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2006},
  volume={17 1-2},
  pages={
          57-68
        }
}
Recent evidences have demonstrated an important role for glomerular visceral epithelial cell (podocyte) in the development and progression of diabetic nephropathy. We investigated the high-glucose (HG)-triggered signaling pathway and its role in matrix metalloproteinase (MMP) production in murine podocytes. The activity of 92-kDa (MMP-9) gelatinase, but not of 72 kDa (MMP-2), in an HG medium significantly increased during incubation of 2 to 3 days and decreased during incubation of more than 5… CONTINUE READING
26 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…