High-altitude pulmonary edema: an immunogenetically mediated disease?

Abstract

High-altitude pulmonary edema (HAPE), a potentially life-threatening complication of acute mountain sickness, is postulated to be a noncardiogenic permeability edema caused by acute pulmonary arteriolar vasoconstriction and resultant pulmonary hypertension in response to the hypoxia of rapid ascent to high altitudes. HAPE typically occurs unexpectedly in… (More)

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