High altitude, hypoxic-induced modulation of noradrenergic-mediated responses in fetal and adult cerebral arteries.


In response to high altitude long-term hypoxemia, the cerebral arteries of adult and fetal sheep show decreased contractile responses to norepinephrine and other agonists. In this review, we examine some of the presynaptic and postsynaptic contractile mechanisms that might account for these changes. In addition, we examine cerebral vessel relaxation and the… (More)


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