High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.

  title={High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.},
  author={Genevi{\`e}ve Escher and Martino Cristiano and Maja Causevic and Marc Baumann and Felix J. Frey and Daniel Surbek and Markus Georg Mohaupt},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={24 6},
BACKGROUND Increased aldosterone concentrations and volume expansion of normal pregnancies are hallmarks of normal pregnancies and blunted in pre-eclampsia. Accordingly, we hypothesized an active mineralocorticoid system to protect from pre-eclampsia. METHODS In pregnant women (normotensive n = 44; pre-eclamptic n = 48), blood pressure, urinary tetrahydro-aldosterone excretion and activating polymorphisms (SF-1 site and intron 2) of the aldosterone synthase gene (CYP11B2) were determined; 185… CONTINUE READING


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