High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain.

@article{Lin2002HighAB,
  title={High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain.},
  author={Michael T. Lin and David K Simon and Colette H Ahn and Lauren M Kim and Myron Flint Beal},
  journal={Human molecular genetics},
  year={2002},
  volume={11 2},
  pages={133-45}
}
The mitochondrial theory of aging proposes that mitochondrial DNA (mtDNA) accumulates mutations with age, and that these mutations contribute to physiological decline in aging and degenerative diseases. Although a great deal of indirect evidence supports this hypothesis, the aggregate burden of mtDNA mutations, particularly point mutations, has not been systematically quantified in aging or neurodegenerative disorders. Therefore, we directly assessed the aggregate burden of brain mtDNA point… CONTINUE READING
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