High affinity retinoic acid receptor antagonists: analogs of AGN 193109.

@article{Johnson1999HighAR,
  title={High affinity retinoic acid receptor antagonists: analogs of AGN 193109.},
  author={A T Johnson and Lili Wang and Steve Gillett and Roshantha A. S. Chandraratna},
  journal={Bioorganic & medicinal chemistry letters},
  year={1999},
  volume={9 4},
  pages={573-6}
}
A series of high affinity retinoic acid receptor (RAR) antagonists were prepared based upon the known antagonist AGN 193109 (2). Introduction of various phenyl groups revealed a preference for substitution at the para-position relative to the meta-site. Antagonists with the highest affinities for the RARs possessed hydrophobic groups, however, the presence of polar functionality was also well tolerated.