High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin.

@article{Saris2001HighaffinityPB,
  title={High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin.},
  author={Jasper J Saris and Frans H. M. Derkx and Ren{\'e} J A de Bruin and Dick H. W. Dekkers and Jos M. J. Lamers and Pramod R. Saxena and Maarten A. D. H. Schalekamp and Alexander H J Danser},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 4},
  pages={H1706-15}
}
Mannose-6-phosphate (man-6-P)/insulin-like growth factor-II (man-6-P/IgF-II) receptors are involved in the activation of recombinant human prorenin by cardiomyocytes. To investigate the kinetics of this process, the nature of activation, the existence of other prorenin receptors, and binding of native prorenin, neonatal rat cardiomyocytes were incubated with recombinant, renal, or amniotic fluid prorenin with or without man-6-P. Intact and activated prorenin were measured in cell lysates with… CONTINUE READING
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