High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat.

Abstract

Phenacetin is metabolized primarily by O-deethylation to paracetamol (POD activity), a reaction catalysed by cytochrome P450. The high affinity component of POD activity is inducible in rat liver by treatment of the animals with polycyclic aromatic hydrocarbons. Following treatment with hydrocarbons such as 3-methylcholanthrene (MC) and isosafrole (ISF… (More)

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@article{Sesardic1990HighAP, title={High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat.}, author={Dorothea Sesardic and Robert J Edwards and Donald S. Davies and Paul E. Thomas and Wayne Levin and Alan Raymond Boobis}, journal={Biochemical pharmacology}, year={1990}, volume={39 3}, pages={489-98} }