High-affinity neuropeptide Y receptor antagonists.

  title={High-affinity neuropeptide Y receptor antagonists.},
  author={Alejandro J Daniels and Julia E Matthews and R J Slepetis and Marilyn Jansen and O. Humberto Viveros and A. S. Tadepalli and William Harrington and Dennis O Heyer and A Landavazo and J J Leban and Andrew Spaltenstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 20},
Neuropeptide Y (NPY) is one of the most abundant peptide transmitters in the mammalian brain. In the periphery it is costored and coreleased with norepinephrine from sympathetic nerve terminals. However, the physiological functions of this peptide remain unclear because of the absence of specific high-affinity receptor antagonists. Three potent NPY receptor antagonists were synthesized and tested for their biological activity in in vitro, ex vivo, and in vivo functional assays. We describe here… CONTINUE READING


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