High affinity ligands from in vitro selection: complex targets.

@article{Morris1998HighAL,
  title={High affinity ligands from in vitro selection: complex targets.},
  author={Kathryn Morris and Kim Bak Jensen and Carol M. Julin and Matthias Weil and Larry Gold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 6},
  pages={2902-7}
}
Human red blood cell membranes were used as a model system to determine if the systematic evolution of ligands by exponential enrichment (SELEX) methodology, an in vitro protocol for isolating high-affinity oligonucleotides that bind specifically to virtually any single protein, could be used with a complex mixture of potential targets. Ligands to multiple targets were generated simultaneously during the selection process, and the binding affinities of these ligands for their targets are… CONTINUE READING

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Morris et al

  • O. Livnah, E. A. Stura, +8 authors 464–471. Biochemistry
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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