High affinity ligands from in vitro selection: complex targets.

  title={High affinity ligands from in vitro selection: complex targets.},
  author={Kathryn Morris and Kim Bak Jensen and Carol M. Julin and Matthias Weil and Larry Gold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 6},
Human red blood cell membranes were used as a model system to determine if the systematic evolution of ligands by exponential enrichment (SELEX) methodology, an in vitro protocol for isolating high-affinity oligonucleotides that bind specifically to virtually any single protein, could be used with a complex mixture of potential targets. Ligands to multiple targets were generated simultaneously during the selection process, and the binding affinities of these ligands for their targets are… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
101 Citations
1 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 101 extracted citations


Publications referenced by this paper.

Morris et al

  • O. Livnah, E. A. Stura, +8 authors 464–471. Biochemistry
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

Similar Papers

Loading similar papers…