High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.

@article{Nezami2003HighaffinityIO,
  title={High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.},
  author={Azin Nezami and Tooru Kimura and Koushi Hidaka and Aiko Kiso and Jun Liu and Yoshiaki Kiso and Daniel E Goldberg and Ernesto Freire},
  journal={Biochemistry},
  year={2003},
  volume={42 28},
  pages={8459-64}
}
Drug development against viral or microbial targets is often compounded by the existence of naturally occurring polymorphisms or drug resistant mutations. In the case of Plasmodium falciparum, the etiological agent of malaria, four related and essential proteases, plasmepsin I, II, and IV and the histo-aspartyl protease (HAP), have been identified in the food vacuole of the parasite. Since all of these enzymes are involved in the hemoglobin degradation of infected victims, the simultaneous… CONTINUE READING

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