High affinity hemoglobin and Parkinson's disease.

  title={High affinity hemoglobin and Parkinson's disease.},
  author={Jeffrey Graham and Douglas E Hobson and Arjuna Ponnampalam},
  journal={Medical hypotheses},
  volume={83 6},
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN) region of the midbrain. Oxidative damage in this region has been shown to play an important role in the pathogenesis of this disease. Human neurons have been discovered to contain hemoglobin, with an increased concentration seen in the neurons of the SN. High affinity hemoglobin is a clinical entity resulting from mutations that create a functional increase in… CONTINUE READING


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