High affinity germinal center B cells are actively selected into the plasma cell compartment

@article{Phan2006HighAG,
  title={High affinity germinal center B cells are actively selected into the plasma cell compartment},
  author={Tri Giang Phan and Didrik Paus and Tyani D Chan and Marian L. Turner and Stephen L Nutt and Antony Basten and Robert Brink},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={2419 - 2424}
}
A hallmark of T cell-dependent immune responses is the progressive increase in the ability of serum antibodies to bind antigen and provide immune protection. Affinity maturation of the antibody response is thought to be connected with the preferential survival of germinal centre (GC) B cells that have acquired increased affinity for antigen via somatic hypermutation of their immunoglobulin genes. However, the mechanisms that drive affinity maturation remain obscure because of the difficulty in… CONTINUE READING