High-affinity fluorescent ligands for the 5-HT3 receptor


The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.

DOI: 10.1016/j.bmcl.2011.11.097
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@inproceedings{Simonin2012HighaffinityFL, title={High-affinity fluorescent ligands for the 5-HT3 receptor}, author={Jonathan Simonin and Sanjeev Kumar V. Vernekar and Andrew J Thompson and J. Daniel Hothersall and Christopher Connolly and Sarah C. R. Lummis and Martin Lochner}, booktitle={Bioorganic & medicinal chemistry letters}, year={2012} }