High affinity epidermal growth factor receptors on the surface of A431 cells have restricted lateral diffusion.

@article{Rees1984HighAE,
  title={High affinity epidermal growth factor receptors on the surface of A431 cells have restricted lateral diffusion.},
  author={Anthony Robert Rees and Mary Gregoriou and Pauline M. Johnson and Peter B. Garland},
  journal={The EMBO journal},
  year={1984},
  volume={3 8},
  pages={
          1843-7
        }
}
Rhodamine-labelled epidermal growth factor (Rh-EGF) was shown to bind to A431 cells grown at low density both to a small number of high affinity receptors (KD = 2.8 X 10(-10) M; fraction of total binding sites approximately 0.12) and also to a large number of low affinity receptors (KD = 4 X 10(-9) M; fraction of total binding sites approximately 0.88). Measurements of the lateral diffusion of EGF receptors on the cell surface were made using Rh-EGF and the technique of fluorescence… CONTINUE READING
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