High affinity binding sites for the Wilms' tumour suppressor protein WT1.

@article{Hamilton1995HighAB,
  title={High affinity binding sites for the Wilms' tumour suppressor protein WT1.},
  author={T B Hamilton and K C Barilla and Paul J. Romaniuk},
  journal={Nucleic acids research},
  year={1995},
  volume={23 2},
  pages={277-84}
}
The Wilms' tumour suppressor protein (WT1) is a putative transcriptional regulatory protein with four zinc fingers, the last three of which have extensive sequence homology to the early growth response-1 (EGR-1) protein. Although a peptide encoding the zinc finger domain of WT1[-KTS] can bind to a consensus 9 bp EGR-1 binding site, current knowledge about the mechanisms of zinc finger-DNA interactions would predict a more extended recognition site for WT1. Using a WT1[-KTS] zinc finger peptide… CONTINUE READING