High affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes

@article{Mellerup2006HighAB,
  title={High affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes},
  author={Erling Mellerup and Per Plenge},
  journal={Psychopharmacology},
  year={2006},
  volume={89},
  pages={436-439}
}
Paroxetine is the most potent and one of the most specific serotonin uptake inhibitors. High-affinity3H-paroxetine and3H-imipramine binding was compared in rat neuronal membranes.TheKd value for3H-paroxetine binding to neuronal membranes was 0.08 nM, which is exactly the same value as with platelet membranes. TheKd value for3H-imipramine binding to neuronal membranes was about 4 nM, which is higher than theKd value for3H-imipramine binding to platelet membranes (0.5 nM).The results indicated… Expand
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