High affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes

  title={High affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes},
  author={E. Mellerup and P. Plenge},
  • E. Mellerup, P. Plenge
  • Published 2006
  • Medicine, Biology
  • Psychopharmacology
  • Paroxetine is the most potent and one of the most specific serotonin uptake inhibitors. High-affinity3H-paroxetine and3H-imipramine binding was compared in rat neuronal membranes.TheKd value for3H-paroxetine binding to neuronal membranes was 0.08 nM, which is exactly the same value as with platelet membranes. TheKd value for3H-imipramine binding to neuronal membranes was about 4 nM, which is higher than theKd value for3H-imipramine binding to platelet membranes (0.5 nM).The results indicated… CONTINUE READING
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