High affinity binding of paclitaxel to human serum albumin.

  title={High affinity binding of paclitaxel to human serum albumin.},
  author={Kriztina Paal and Jan Philippe M{\"u}ller and Lajos Hegedus},
  journal={European journal of biochemistry},
  volume={268 7},
Paclitaxel, a very potent antitumor agent is a hydrophobic molecule with low aqueous solubility. Its currently used formula (Taxol) contains the drug in a 1 : 1 (v/v) mixture of ethanol and Cremophor EL. To minimize vehicle-related toxicity, we developed a novel, water-soluble formulation in which paclitaxel is bound noncovalently to human serum albumin. For this purpose, studies of the paclitaxel-albumin binding equilibrium were performed. Paclitaxel dissolved in ethanol was added to the… CONTINUE READING


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