High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons.

@article{Herrick2004HighAB,
  title={High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons.},
  author={Tara M. Herrick and Jonathan A Cooper},
  journal={Brain research. Molecular brain research},
  year={2004},
  volume={126 2},
  pages={121-8}
}
The positions of neurons in the neocortex, hippocampus, cerebellum and various other laminated brain regions are regulated by a signaling pathway initiated by the secreted protein Reelin and requiring the intracellular adaptor protein Dab1. Dab1 and the Reelin receptors VLDLR and ApoER2 are expressed by neurons whose migrations are coordinated by Reelin. In vitro, Dab1 binds with high affinity to the cytoplasmic tails of VLDLR and ApoER2 via its PTB domain. To test the importance of Dab1… CONTINUE READING

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