High affinity binding of [3H]-tyramine in the central nervous system.

@article{Vaccari1986HighAB,
  title={High affinity binding of [3H]-tyramine in the central nervous system.},
  author={Andrea Vaccari},
  journal={British journal of pharmacology},
  year={1986},
  volume={89 1},
  pages={15-25}
}
Optimum assay conditions for the association of [3H]-para-tyramine [( 3H]-pTA) with rat brain membranes were characterized, and a saturable, reversible, drug-specific, and high affinity binding mechanism for this trace amine was revealed. The binding capacity (Bmax) for [3H]-pTA in the corpus striatum was approximately 30 times higher than that in the cerebellum, with similar dissociation constants (KD). The binding process of [3H]-pTA involved the dopamine system, inasmuch as (a) highest… CONTINUE READING
11 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…