High affinity binding of [3H]-tyramine in the central nervous system.

  title={High affinity binding of [3H]-tyramine in the central nervous system.},
  author={Andrea Vaccari},
  journal={British journal of pharmacology},
  volume={89 1},
Optimum assay conditions for the association of [3H]-para-tyramine [( 3H]-pTA) with rat brain membranes were characterized, and a saturable, reversible, drug-specific, and high affinity binding mechanism for this trace amine was revealed. The binding capacity (Bmax) for [3H]-pTA in the corpus striatum was approximately 30 times higher than that in the cerebellum, with similar dissociation constants (KD). The binding process of [3H]-pTA involved the dopamine system, inasmuch as (a) highest… CONTINUE READING
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