High affinity binding and direct antiproliferative effects of luteinizing hormone-releasing hormone analogs in human endometrial cancer cell lines.

@article{Emons1993HighAB,
  title={High affinity binding and direct antiproliferative effects of luteinizing hormone-releasing hormone analogs in human endometrial cancer cell lines.},
  author={Gu Nter Emons and Bernd Schroeder and Olaf Ortmann and Silke Westphalen and Klaus Schulz and Andrew V Schally},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={77 6},
  pages={1458-64}
}
Although specific binding sites for LH-releasing hormone (LHRH) and its analogs have been demonstrated in biopsy samples of human endometrial cancer, their biological significance remains obscure. In this study we evaluated whether binding sites for LHRH are also present in the human endometrial cancer cell lines HEC-1A and Ishikawa and if such sites could mediate antiproliferative effects of LHRH analogs. Using [125I,D-Trp6]LHRH as a ligand, a high affinity/low capacity binding site was… CONTINUE READING

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